DegronMD

Uniprot ID: Q9NRF8

Source protein: CTP synthase 2

Source gene: CTPS2

Class: LIG_APCC_ABBA_1

Location: 80:85

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5001

ASA_SCORE: 55.8

COIL: 0.6365

CONS_SCORE: 0.5098

DSS_SCORE: 0.1024

HELIX: 0.0573

FCONS_SCORE: 0.657

RIG_SCORE: 0.9035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K92N	TCGA-B5-A0JY	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	0.5833
p.K92N	DO43041	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	0.5833
p.R76I	TCGA-B6-A0X5	BRCA	TCGA	INLYKD	LIG_APCC_ABBA_1	0.2222
p.R76I	DO2096	BRCA	ICGC	INLYKD	LIG_APCC_ABBA_1	0.2222
p.G91V	TCGA-D1-A17D	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	0.1667
p.G91V	DO41746	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	0.1667
p.E75D	TCGA-EO-A3AV	UCEC	TCGA	INLYKD	LIG_APCC_ABBA_1	0.1944
p.E75D	DO52412	UCEC	ICGC	INLYKD	LIG_APCC_ABBA_1	0.1944
p.I93T	TCGA-UF-A71B	HNSC	TCGA	INLYKD	LIG_APCC_ABBA_1	0.1111
p.I93T	DO52107	HNSC	ICGC	INLYKD	LIG_APCC_ABBA_1	0.1111
p.N87S	DO232028	LICA	ICGC	INLYKD	LIG_APCC_ABBA_1	0.2778
p.N86K	DO229025	LICA	ICGC	INLYKD	LIG_APCC_ABBA_1	0.3056
p.N86Y	DO231186	LUSC	ICGC	INLYKD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRF8	CTP synthase 2	LIG_APCC_ABBA_1	80:85	INLYKD	APC,CDC20,FZR1	0.5001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons