DegronMD - Q9NRH2(SNRK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R567L	TCGA-A6-6653	COAD	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2222
p.R567L	DO10373	COAD	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2222
p.R552W	TCGA-EI-6917	READ	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1944
p.R552W	TCGA-EY-A1GQ	UCEC	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1944
p.R552W	DO36881	READ	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1944
p.R552W	DO43090	UCEC	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1944
p.D555N	DO223068	ESCA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2778
p.D555N	SIDM00217	Colorectal Carcinoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2778
p.D555N	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2778
p.D555N	SNU-1040	large intestine	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2778
p.E571K	DO233882	GACA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1111
p.R552Q	DO231956	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.1944
p.W564C	DO229037	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.3056
p.S569I	DO229045	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation blocking phosphorylation signal	0.6111
p.S550G	DO45273	LIRI	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation blocking phosphorylation signal	0.5833
p.G559R	SIDM00662	Melanoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation altering degron motif	0.7568
p.G559R	ACH-000135	Non-Cancerous	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation altering degron motif	0.7568
p.G559R	Hs940-T	skin	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation altering degron motif	0.7568
p.L554V	SIDM00664	Pancreatic Carcinoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.25
p.L554V	ACH-000178	Pancreatic Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.25
p.L554V	Hs766T	pancreas	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.25
p.R553Q	ACH-001786	Colon/Colorectal Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	557:563	Mutation rewiring degron network	0.2222

Kaplan plot for SNRK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNRK

UniProt ID: Q9NRH2

Entrez ID: 54861

Protein name: SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1-related kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNRK in