DegronMD

Uniprot ID: Q9NRH2

Source protein: SNF-related serine/threonine-protein kinase

Source gene: SNRK

Class: DEG_SCF_TRCP1_1

Location: 557:563

E3 ligase: BTRC

DEGRON score: 0.9959

ASA_SCORE: 78.5429

COIL: 0.8649

CONS_SCORE: 0.328

DSS_SCORE: 0.5666

HELIX: 0.0713

FCONS_SCORE: 0.9341

RIG_SCORE: 0.6536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R567L	TCGA-A6-6653	COAD	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	0.2222
p.R567L	DO10373	COAD	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.2222
p.R552W	TCGA-EI-6917	READ	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	0.1944
p.R552W	TCGA-EY-A1GQ	UCEC	TCGA	DSGFTYS	DEG_SCF_TRCP1_1	0.1944
p.R552W	DO36881	READ	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.1944
p.R552W	DO43090	UCEC	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.1944
p.D555N	DO223068	ESCA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.2778
p.D555N	SIDM00217	Colorectal Carcinoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	0.2778
p.D555N	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	0.2778
p.D555N	SNU-1040	large_intestine	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	0.2778
p.E571K	DO233882	GACA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.1111
p.R552Q	DO231956	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.1944
p.W564C	DO229037	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.3056
p.S569I	DO229045	LICA	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.6111
p.S550G	DO45273	LIRI	ICGC	DSGFTYS	DEG_SCF_TRCP1_1	0.5833
p.G559R	SIDM00662	Melanoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	0.7568
p.G559R	ACH-000135	Non-Cancerous	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	0.7568
p.G559R	Hs940-T	skin	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	0.7568
p.L554V	SIDM00664	Pancreatic Carcinoma	GDSC	DSGFTYS	DEG_SCF_TRCP1_1	0.25
p.L554V	ACH-000178	Pancreatic Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	0.25
p.L554V	Hs766T	pancreas	COSMIC	DSGFTYS	DEG_SCF_TRCP1_1	0.25
p.R553Q	ACH-001786	Colon/Colorectal Cancer	CCLE	DSGFTYS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRH2	SNF-related serine/threonine-protein kinase	DEG_SCF_TRCP1_1	557:563	DSGFTYS	BTRC	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons