DegronMD - Q9NRJ7(PCDHB16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V549L	TCGA-28-1753	GBM	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.5654
p.V549L	DO11687	GBM	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.5654
p.R536H	TCGA-2F-A9KP	BLCA	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1667
p.R536H	DO51860	BLCA	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1667
p.L552M	TCGA-2W-A8YY	CESC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2778
p.L552M	DO223732	CESC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2778
p.P539T	TCGA-44-3918	LUAD	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.25
p.P539T	DO23732	LUAD	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.25
p.S538F	TCGA-BA-A6DJ	HNSC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2222
p.S538F	DO52034	HNSC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2222
p.L546P	TCGA-BG-A222	UCEC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.7582
p.L546P	DO42977	UCEC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.7582
p.E544K	TCGA-F5-6811	READ	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.E544K	TCGA-FS-A1ZW	SKCM	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.E544K	TCGA-MY-A913	CESC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.E544K	DO49980	CESC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.E544K	DO37082	READ	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.E544K	DO37519	SKCM	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.591
p.D556Y	TCGA-OR-A5KB	ACC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1667
p.A554T	DO227950	BRCA	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.2222
p.S543R	DO50999	LAML	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.7427
p.S543R	DO23496	LINC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.7427
p.S543R	DO23466	LINC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation altering degron motif	0.7427
p.S532G	DO231154	LAML	ICGC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.0556
p.G537S	ACH-000793	Gastric Cancer	CCLE	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1944
p.G537S	KATOIII	stomach	COSMIC	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1944
p.D535Y	ACH-000931	Skin Cancer	CCLE	SREALVRVL	DEG_APCC_DBOX_1	542:550	Mutation rewiring degron network	0.1389

Kaplan plot for PCDHB16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHB16

UniProt ID: Q9NRJ7

Entrez ID: 57717

Protein name: Protocadherin beta-16 (PCDH-beta-16) (Protocadherin-3X)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHB16 in