DegronMD

Uniprot ID: Q9NRJ7

Source protein: Protocadherin beta-16

Source gene: PCDHB16

Class: DEG_APCC_DBOX_1

Location: 542:550

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5333

ASA_SCORE: 48.4222

COIL: 0.1878

CONS_SCORE: 0.5085

DSS_SCORE: 0.1578

HELIX: 0.0066

FCONS_SCORE: 0.8634

RIG_SCORE: 0.8746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V549L	TCGA-28-1753	GBM	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.5654
p.V549L	DO11687	GBM	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.5654
p.R536H	TCGA-2F-A9KP	BLCA	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.1667
p.R536H	DO51860	BLCA	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.1667
p.L552M	TCGA-2W-A8YY	CESC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.2778
p.L552M	DO223732	CESC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.2778
p.P539T	TCGA-44-3918	LUAD	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.25
p.P539T	DO23732	LUAD	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.25
p.S538F	TCGA-BA-A6DJ	HNSC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.2222
p.S538F	DO52034	HNSC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.2222
p.L546P	TCGA-BG-A222	UCEC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.7582
p.L546P	DO42977	UCEC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.7582
p.E544K	TCGA-F5-6811	READ	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.E544K	TCGA-FS-A1ZW	SKCM	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.E544K	TCGA-MY-A913	CESC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.E544K	DO49980	CESC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.E544K	DO37082	READ	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.E544K	DO37519	SKCM	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.591
p.D556Y	TCGA-OR-A5KB	ACC	TCGA	SREALVRVL	DEG_APCC_DBOX_1	0.1667
p.A554T	DO227950	BRCA	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.2222
p.S543R	DO50999	LAML	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.7427
p.S543R	DO23496	LINC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.7427
p.S543R	DO23466	LINC	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.7427
p.S532G	DO231154	LAML	ICGC	SREALVRVL	DEG_APCC_DBOX_1	0.0556
p.G537S	ACH-000793	Gastric Cancer	CCLE	SREALVRVL	DEG_APCC_DBOX_1	0.1944
p.G537S	KATOIII	stomach	COSMIC	SREALVRVL	DEG_APCC_DBOX_1	0.1944
p.D535Y	ACH-000931	Skin Cancer	CCLE	SREALVRVL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRJ7	Protocadherin beta-16	DEG_APCC_DBOX_1	542:550	SREALVRVL	APC,CDC20,FZR1	0.5333	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREALVRVL

Degron related mutations and impact score

Drug responses associated with PCDHB16 mutations

All proteins holding degron of SREALVRVL