DegronMD - Q9NRS6(SNX15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P176A	TCGA-DM-A1DA	COAD	TCGA	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1944
p.P176A	DO7852	COAD	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1944
p.S179F	TCGA-WE-AAA0	SKCM	TCGA	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1111
p.S179F	DO51294	SKCM	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1111
p.S180N	DO233211	GACA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.0833
p.P177Q	DO47140	RECA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.P176L	DO229465	SKCA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1944
p.P173Q	DO229259	THCA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2778
p.R164K	ACH-000928	Endometrial/Uterine Cancer	CCLE	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7237
p.V172M	ACH-000995	Leukemia	CCLE	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.3056
p.V172M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ERRGLEELE	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons