DegronMD

Uniprot ID: Q9NRS6

Source protein: Sorting nexin-15

Source gene: SNX15

Class: DEG_APCC_DBOX_1

Location: 163:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9046

ASA_SCORE: 105.6111

COIL: 0.5168

CONS_SCORE: 0.4447

DSS_SCORE: 0.6394

HELIX: 0.4626

FCONS_SCORE: 1.0307

RIG_SCORE: 0.6631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P176A	TCGA-DM-A1DA	COAD	TCGA	ERRGLEELE	DEG_APCC_DBOX_1	0.1944
p.P176A	DO7852	COAD	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.1944
p.S179F	TCGA-WE-AAA0	SKCM	TCGA	ERRGLEELE	DEG_APCC_DBOX_1	0.1111
p.S179F	DO51294	SKCM	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.1111
p.S180N	DO233211	GACA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.0833
p.P177Q	DO47140	RECA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.1667
p.P176L	DO229465	SKCA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.1944
p.P173Q	DO229259	THCA	ICGC	ERRGLEELE	DEG_APCC_DBOX_1	0.2778
p.R164K	ACH-000928	Endometrial/Uterine Cancer	CCLE	ERRGLEELE	DEG_APCC_DBOX_1	0.7237
p.V172M	ACH-000995	Leukemia	CCLE	ERRGLEELE	DEG_APCC_DBOX_1	0.3056
p.V172M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ERRGLEELE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRS6	Sorting nexin-15	DEG_APCC_DBOX_1	163:171	ERRGLEELE	APC,CDC20,FZR1	0.9046	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons