DegronMD - Q9NRW4(DUSP22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D57N	TCGA-06-5416	GBM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1111
p.D57N	DO10880	GBM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1111
p.D57N	DO232224	PBCA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1111
p.V48F	TCGA-14-1825	GBM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7068
p.V48F	DO13090	GBM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7068
p.S40R	TCGA-22-4593	LUSC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.3056
p.S40R	DO27018	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.3056
p.P59Q	TCGA-55-8302	LUAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.P59Q	DO45312	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.H38N	TCGA-78-7542	LUAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.H38N	DO24760	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.Y50C	TCGA-AA-3715	COAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.3056
p.Y50C	DO8018	COAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.3056
p.A56V	TCGA-BR-6452	STAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A56V	TCGA-BS-A0TG	UCEC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A56V	DO38404	STAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A56V	DO42209	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.E46K	TCGA-D3-A8GM	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.591
p.E46K	DO50288	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.591
p.D39N	TCGA-DA-A1HY	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.D39N	TCGA-DA-A1IC	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.D39N	DO37409	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.D39N	DO37430	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.P59S	TCGA-DU-6392	LGG	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.P59S	DO22237	LGG	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.S36C	TCGA-DX-AB35	SARC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.6389
p.S36C	DO220104	SARC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.6389
p.H38R	TCGA-EI-6917	READ	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.H38R	DO36881	READ	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.S58L	TCGA-ER-A194	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.S58L	DO47646	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.S58L	SIDM00087	Plasma Cell Myeloma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.S58L	ACH-000817	Myeloma	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.S58L	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.E39V	DO9282	COAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.E39V	DO219199	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.M44I	DO234270	ESAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6507
p.H41N	DO223267	HNSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7423
p.H41N	DO50118	STAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7423
p.D58E	DO23010	LIHC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.5278
p.A59P	DO23759	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.A59E	DO23678	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.E36Q	DO224563	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation blocking phosphorylation signal	0.6389
p.E39D	DO26452	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.E39D	MFE-296	endometrium	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.E49K	DO220877	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7022
p.E49K	DO51298	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7022
p.P55L	DO220902	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1667
p.I34V	DO220906	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.1389
p.A59V	DO30860	OV	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.0556
p.R44W	DO37567	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8634
p.R44W	DO37446	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8634
p.G52E	DO37425	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.E53K	DO50288	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2222
p.G52R	DO38111	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.G52R	DO41999	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.25
p.R44Q	DO42568	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.7329
p.A41G	SIDM00179	Melanoma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6429
p.A41G	ACH-002165	Skin Cancer	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6429
p.A41G	MZ2-MEL	skin	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6429
p.G47R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6457
p.G47R	NCI-H1435	lung	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.6457
p.L51P	ACH-001388	Breast Cancer	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation rewiring degron network	0.2778
p.R44L	NCI-H1734	lung	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	41:49	Mutation altering degron motif	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP22

UniProt ID: Q9NRW4

Entrez ID: 56940

Protein name: Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP22 in