DegronMD

Uniprot ID: Q9NRW4

Source protein: Dual specificity protein phosphatase 22

Source gene: DUSP22

Class: DEG_APCC_DBOX_1

Location: 41:49

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9612

ASA_SCORE: 75.2444

COIL: 0.812

CONS_SCORE: 0.4127

DSS_SCORE: 0.1799

HELIX: 0.0386

FCONS_SCORE: 0.7055

RIG_SCORE: 0.7612

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D57N	TCGA-06-5416	GBM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.1111
p.D57N	DO10880	GBM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1111
p.D57N	DO232224	PBCA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1111
p.V48F	TCGA-14-1825	GBM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.7068
p.V48F	DO13090	GBM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7068
p.S40R	TCGA-22-4593	LUSC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.3056
p.S40R	DO27018	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.3056
p.P59Q	TCGA-55-8302	LUAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.P59Q	DO45312	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.H38N	TCGA-78-7542	LUAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.H38N	DO24760	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.Y50C	TCGA-AA-3715	COAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.3056
p.Y50C	DO8018	COAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.3056
p.A56V	TCGA-BR-6452	STAD	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.1389
p.A56V	TCGA-BS-A0TG	UCEC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.1389
p.A56V	DO38404	STAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1389
p.A56V	DO42209	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1389
p.E46K	TCGA-D3-A8GM	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.591
p.E46K	DO50288	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.591
p.D39N	TCGA-DA-A1HY	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.D39N	TCGA-DA-A1IC	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.D39N	DO37409	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.D39N	DO37430	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.P59S	TCGA-DU-6392	LGG	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.P59S	DO22237	LGG	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.S36C	TCGA-DX-AB35	SARC	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.6389
p.S36C	DO220104	SARC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6389
p.H38R	TCGA-EI-6917	READ	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.H38R	DO36881	READ	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.S58L	TCGA-ER-A194	SKCM	TCGA	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.S58L	DO47646	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.S58L	SIDM00087	Plasma Cell Myeloma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.S58L	ACH-000817	Myeloma	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.S58L	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.E39V	DO9282	COAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.E39V	DO219199	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.M44I	DO234270	ESAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6507
p.H41N	DO223267	HNSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7423
p.H41N	DO50118	STAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7423
p.D58E	DO23010	LIHC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.5278
p.A59P	DO23759	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.A59E	DO23678	LUAD	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.E36Q	DO224563	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6389
p.E39D	DO26452	LUSC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.E39D	MFE-296	endometrium	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.E49K	DO220877	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7022
p.E49K	DO51298	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7022
p.P55L	DO220902	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1667
p.I34V	DO220906	MELA	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.1389
p.A59V	DO30860	OV	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.0556
p.R44W	DO37567	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.8634
p.R44W	DO37446	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.8634
p.G52E	DO37425	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.E53K	DO50288	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.2222
p.G52R	DO38111	SKCM	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.G52R	DO41999	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.25
p.R44Q	DO42568	UCEC	ICGC	ARPMLEGVK	DEG_APCC_DBOX_1	0.7329
p.A41G	SIDM00179	Melanoma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6429
p.A41G	ACH-002165	Skin Cancer	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	0.6429
p.A41G	MZ2-MEL	skin	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6429
p.G47R	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6457
p.G47R	NCI-H1435	lung	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	0.6457
p.L51P	ACH-001388	Breast Cancer	CCLE	ARPMLEGVK	DEG_APCC_DBOX_1	0.2778
p.R44L	NCI-H1734	lung	COSMIC	ARPMLEGVK	DEG_APCC_DBOX_1	0.8428

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARPMLEGVK

Degron related mutations and impact score

Drug responses associated with DUSP22 mutations

All proteins holding degron of ARPMLEGVK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRW4	Dual specificity protein phosphatase 22	DEG_APCC_DBOX_1	41:49	ARPMLEGVK	APC,CDC20,FZR1	0.9612	More...