DegronMD - Q9NS28(RGS18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R62S	TCGA-05-4396	LUAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R62S	DO23838	LUAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.E56A	TCGA-55-8204	LUAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.E56A	DO45322	LUAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.R45I	TCGA-63-A5MU	LUSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8102
p.R45I	DO219165	LUSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.8102
p.E36K	TCGA-A5-A0G2	UCEC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E36K	TCGA-CV-5978	HNSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E36K	TCGA-DU-6392	LGG	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E36K	DO16023	HNSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E36K	DO22237	LGG	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.E36K	DO41235	UCEC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1111
p.K38N	TCGA-A6-3810	COAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation substituting flanking lysine	0.2778
p.K38N	TCGA-CA-6717	COAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation substituting flanking lysine	0.2778
p.K38N	DO9434	COAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation substituting flanking lysine	0.2778
p.K38N	DO8264	COAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation substituting flanking lysine	0.2778
p.T61A	TCGA-AJ-A5DW	UCEC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0833
p.T61A	DO50075	UCEC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0833
p.R62H	TCGA-B0-5712	KIRC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R62H	DO20318	KIRC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.E56V	TCGA-BR-6566	STAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.E56V	DO233226	GACA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.E56V	DO38217	STAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.R47T	TCGA-CC-5259	LIHC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.6765
p.R47T	DO44886	LIHC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.6765
p.E43K	TCGA-GN-A269	SKCM	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.3056
p.E43K	DO218847	SKCA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.3056
p.E43K	DO37483	SKCM	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.3056
p.R62C	TCGA-IN-A6RP	STAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R62C	DO51741	STAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.R40T	TCGA-NC-A5HQ	LUSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.2222
p.S34R	TCGA-OR-A5KB	ACC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.S34R	TCGA-XF-A9ST	BLCA	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.S34R	DO223599	BLCA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.0556
p.A37D	TCGA-OR-A5KB	ACC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.1389
p.Q53L	DO231127	LUSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.3056
p.K38Q	SIDM02069	Colorectal Carcinoma	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation substituting flanking lysine	0.2778
p.P55T	SIDM00569	Osteosarcoma	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.25
p.P55T	ACH-002178	Bone Cancer	CCLE	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.25
p.P55T	NY	bone	COSMIC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation rewiring degron network	0.25
p.R45G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	44:52	Mutation altering degron motif	0.7568

Kaplan plot for RGS18 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS18

UniProt ID: Q9NS28

Entrez ID: 64407

Protein name: Regulator of G-protein signaling 18 (RGS18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS18 in