DegronMD

Uniprot ID: Q9NS28

Source protein: Regulator of G-protein signaling 18

Source gene: RGS18

Class: DEG_APCC_DBOX_1

Location: 44:52

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.545

ASA_SCORE: 72.9667

COIL: 0.1956

CONS_SCORE: 0.5464

DSS_SCORE: 0.5189

HELIX: 0.7956

FCONS_SCORE: 1.0515

RIG_SCORE: 0.7569

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R62S	TCGA-05-4396	LUAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.R62S	DO23838	LUAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.E56A	TCGA-55-8204	LUAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.E56A	DO45322	LUAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.R45I	TCGA-63-A5MU	LUSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.8102
p.R45I	DO219165	LUSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.8102
p.E36K	TCGA-A5-A0G2	UCEC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.E36K	TCGA-CV-5978	HNSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.E36K	TCGA-DU-6392	LGG	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.E36K	DO16023	HNSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.E36K	DO22237	LGG	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.E36K	DO41235	UCEC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.1111
p.K38N	TCGA-A6-3810	COAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.2778
p.K38N	TCGA-CA-6717	COAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.2778
p.K38N	DO9434	COAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2778
p.K38N	DO8264	COAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2778
p.T61A	TCGA-AJ-A5DW	UCEC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0833
p.T61A	DO50075	UCEC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.0833
p.R62H	TCGA-B0-5712	KIRC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.R62H	DO20318	KIRC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.E56V	TCGA-BR-6566	STAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.E56V	DO233226	GACA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.E56V	DO38217	STAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.R47T	TCGA-CC-5259	LIHC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.6765
p.R47T	DO44886	LIHC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.6765
p.E43K	TCGA-GN-A269	SKCM	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.3056
p.E43K	DO218847	SKCA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.3056
p.E43K	DO37483	SKCM	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.3056
p.R62C	TCGA-IN-A6RP	STAD	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.R62C	DO51741	STAD	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.R40T	TCGA-NC-A5HQ	LUSC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.2222
p.S34R	TCGA-OR-A5KB	ACC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.S34R	TCGA-XF-A9ST	BLCA	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.S34R	DO223599	BLCA	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.0556
p.A37D	TCGA-OR-A5KB	ACC	TCGA	KRNRLSLLV	DEG_APCC_DBOX_1	0.1389
p.Q53L	DO231127	LUSC	ICGC	KRNRLSLLV	DEG_APCC_DBOX_1	0.3056
p.K38Q	SIDM02069	Colorectal Carcinoma	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	0.2778
p.P55T	SIDM00569	Osteosarcoma	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	0.25
p.P55T	ACH-002178	Bone Cancer	CCLE	KRNRLSLLV	DEG_APCC_DBOX_1	0.25
p.P55T	NY	bone	COSMIC	KRNRLSLLV	DEG_APCC_DBOX_1	0.25
p.R45G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	KRNRLSLLV	DEG_APCC_DBOX_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRNRLSLLV

Degron related mutations and impact score

Drug responses associated with RGS18 mutations

All proteins holding degron of KRNRLSLLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS28	Regulator of G-protein signaling 18	DEG_APCC_DBOX_1	44:52	KRNRLSLLV	APC,CDC20,FZR1	0.545	More...