DegronMD - Q9NS86(LANCL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M19V	TCGA-A6-2675	COAD	TCGA	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.1667
p.M19V	DO8594	COAD	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.1667
p.E16K	TCGA-EE-A29A	SKCM	TCGA	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.0833
p.E16K	DO37416	SKCM	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.0833
p.A40T	DO229027	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.0556
p.G36V	DO229032	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.1667
p.G36V	DO229037	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.1667
p.R22L	DO229009	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.25
p.P29S	DO222363	MELA	ICGC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation altering degron motif	0.5641
p.A23T	SIDM00572	Gastric Carcinoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.2778
p.A23T	ACH-000911	Gastric Cancer	CCLE	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation rewiring degron network	0.2778
p.D30H	SIDM01196	Hepatocellular Carcinoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation altering degron motif	0.7688
p.D30H	SNU-475	liver	COSMIC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation altering degron motif	0.7688
p.P29L	SIDM01446	Glioblastoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation altering degron motif	0.6471
p.P29L	ACH-000543	Brain Cancer	CCLE	VNPFPD	LIG_APCC_ABBA_1	25:30	Mutation altering degron motif	0.6471

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons