DegronMD

Uniprot ID: Q9NS86

Source protein: LanC-like protein 2

Source gene: LANCL2

Class: LIG_APCC_ABBA_1

Location: 25:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.996

ASA_SCORE: 70.0167

COIL: 0.8398

CONS_SCORE: 0.4252

DSS_SCORE: 0.3593

HELIX: 0.0903

FCONS_SCORE: 1.5215

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M19V	TCGA-A6-2675	COAD	TCGA	VNPFPD	LIG_APCC_ABBA_1	0.1667
p.M19V	DO8594	COAD	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.1667
p.E16K	TCGA-EE-A29A	SKCM	TCGA	VNPFPD	LIG_APCC_ABBA_1	0.0833
p.E16K	DO37416	SKCM	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.0833
p.A40T	DO229027	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.0556
p.G36V	DO229032	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.1667
p.G36V	DO229037	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.1667
p.R22L	DO229009	LICA	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.25
p.P29S	DO222363	MELA	ICGC	VNPFPD	LIG_APCC_ABBA_1	0.5641
p.A23T	SIDM00572	Gastric Carcinoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	0.2778
p.A23T	ACH-000911	Gastric Cancer	CCLE	VNPFPD	LIG_APCC_ABBA_1	0.2778
p.D30H	SIDM01196	Hepatocellular Carcinoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	0.7688
p.D30H	SNU-475	liver	COSMIC	VNPFPD	LIG_APCC_ABBA_1	0.7688
p.P29L	SIDM01446	Glioblastoma	GDSC	VNPFPD	LIG_APCC_ABBA_1	0.6471
p.P29L	ACH-000543	Brain Cancer	CCLE	VNPFPD	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS86	LanC-like protein 2	LIG_APCC_ABBA_1	25:30	VNPFPD	APC,CDC20,FZR1	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons