DegronMD - Q9NS98(SEMA3G)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A756V	TCGA-A5-A0G1	UCEC	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.0833
p.A756V	DO42472	UCEC	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.0833
p.T775M	TCGA-AG-4008	READ	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.2222
p.T775M	DO36386	READ	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.2222
p.R774W	TCGA-B5-A11E	UCEC	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.25
p.R774W	DO41644	UCEC	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.25
p.E778K	TCGA-D3-A8GL	SKCM	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1389
p.E778K	DO50287	SKCM	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1389
p.R777W	TCGA-FD-A6TF	BLCA	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.R777W	DO51880	BLCA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.R777W	SIDM00717	Non-Cancerous	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.R777W	SIDM00472	Ovarian Carcinoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.R777W	SIDM01711	Non-Cancerous	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.R777W	SIDM00542	Glioblastoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1667
p.A756T	TCGA-ND-A4WC	UCS	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.0833
p.G757W	DO234404	ESAD	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1111
p.H772Q	DO228948	LICA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.3056
p.S766R	DO229022	LICA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation altering degron motif	0.6316
p.E771Q	DO222591	MELA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation altering degron motif	0.6744
p.P776S	SIDM01009	Neuroblastoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1944
p.P776S	ACH-000259	Neuroblastoma	CCLE	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1944
p.P776S	KELLY	autonomic ganglia	COSMIC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation rewiring degron network	0.1944
p.A770S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation altering degron motif	0.6477
p.A770S	ACH-001127	Leukemia	CCLE	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation altering degron motif	0.6477
p.A770S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	765:771	Mutation altering degron motif	0.6477

Kaplan plot for SEMA3G in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEMA3G

UniProt ID: Q9NS98

Entrez ID: 56920

Protein name: Semaphorin-3G (Semaphorin sem2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEMA3G in