DegronMD

Uniprot ID: Q9NS98

Source protein: Semaphorin-3G

Source gene: SEMA3G

Class: LIG_APCC_ABBAyCdc20_2

Location: 765:771

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.911

ASA_SCORE: 108.0143

COIL: 0.8393

CONS_SCORE: 0.3413

DSS_SCORE: 0.638

HELIX: 0.127

FCONS_SCORE: 0.8424

RIG_SCORE: 0.6707

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A756V	TCGA-A5-A0G1	UCEC	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A756V	DO42472	UCEC	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T775M	TCGA-AG-4008	READ	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T775M	DO36386	READ	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R774W	TCGA-B5-A11E	UCEC	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.25
p.R774W	DO41644	UCEC	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.25
p.E778K	TCGA-D3-A8GL	SKCM	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E778K	DO50287	SKCM	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R777W	TCGA-FD-A6TF	BLCA	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R777W	DO51880	BLCA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R777W	SIDM00717	Non-Cancerous	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R777W	SIDM00472	Ovarian Carcinoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R777W	SIDM01711	Non-Cancerous	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R777W	SIDM00542	Glioblastoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A756T	TCGA-ND-A4WC	UCS	TCGA	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G757W	DO234404	ESAD	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H772Q	DO228948	LICA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S766R	DO229022	LICA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.6316
p.E771Q	DO222591	MELA	ICGC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.6744
p.P776S	SIDM01009	Neuroblastoma	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P776S	ACH-000259	Neuroblastoma	CCLE	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P776S	KELLY	autonomic_ganglia	COSMIC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A770S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A770S	ACH-001127	Leukemia	CCLE	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.6477
p.A770S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	KSRVHAE	LIG_APCC_ABBAyCdc20_2	0.6477

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KSRVHAE

Degron related mutations and impact score

Drug responses associated with SEMA3G mutations

All proteins holding degron of KSRVHAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS98	Semaphorin-3G	LIG_APCC_ABBAyCdc20_2	765:771	KSRVHAE	APC,CDC20,FZR1	0.911	More...