DegronMD - Q9NSB4(KRT82)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G471C	TCGA-44-2659	LUAD	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.0833
p.G471C	DO23744	LUAD	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.0833
p.A448S	TCGA-63-A5MU	LUSC	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1111
p.A448S	DO219165	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1111
p.V465I	TCGA-AG-3883	READ	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.V465I	DO37010	READ	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.L450M	TCGA-AN-A046	BRCA	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1667
p.L450M	DO1285	BRCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1667
p.E452K	TCGA-BF-AAOX	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2222
p.E452K	TCGA-EB-A24D	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2222
p.E452K	DO37440	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2222
p.E452K	DO223907	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2222
p.L461F	TCGA-EB-A5SE	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.587
p.L461F	DO47295	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.587
p.R467S	TCGA-ER-A19N	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1944
p.R467S	DO37452	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1944
p.T458M	DO228483	BRCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7423
p.T458M	DO230538	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7423
p.T458M	DO230993	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7423
p.T458M	DO231007	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7423
p.L461I	DO48292	ESCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.6063
p.P459T	DO228971	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7031
p.T458K	DO229022	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.7306
p.P453Q	DO229026	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.P453T	DO229034	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.K446Q	DO229227	THCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	456:462	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT82

UniProt ID: Q9NSB4

Entrez ID: 3888

Protein name: Keratin, type II cuticular Hb2 (Keratin-82) (K82) (Type II hair keratin Hb2) (Type-II keratin Kb22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT82 in