DegronMD

Uniprot ID: Q9NSB4

Source protein: Keratin, type II cuticular Hb2

Source gene: KRT82

Class: DEG_SCF_FBW7_1

Location: 456:462

E3 ligase: FBXW7

DEGRON score: 0.7223

ASA_SCORE: 77.8714

COIL: 0.8463

CONS_SCORE: 0.8466

DSS_SCORE: 0.1416

HELIX: 0.0301

FCONS_SCORE: 1.0262

RIG_SCORE: 0.81

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G471C	TCGA-44-2659	LUAD	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.0833
p.G471C	DO23744	LUAD	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.0833
p.A448S	TCGA-63-A5MU	LUSC	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.1111
p.A448S	DO219165	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.1111
p.V465I	TCGA-AG-3883	READ	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.25
p.V465I	DO37010	READ	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.25
p.L450M	TCGA-AN-A046	BRCA	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.1667
p.L450M	DO1285	BRCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.1667
p.E452K	TCGA-BF-AAOX	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.2222
p.E452K	TCGA-EB-A24D	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.2222
p.E452K	DO37440	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.2222
p.E452K	DO223907	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.2222
p.L461F	TCGA-EB-A5SE	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.587
p.L461F	DO47295	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.587
p.R467S	TCGA-ER-A19N	SKCM	TCGA	VSTPVLS	DEG_SCF_FBW7_1	0.1944
p.R467S	DO37452	SKCM	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.1944
p.T458M	DO228483	BRCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7423
p.T458M	DO230538	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7423
p.T458M	DO230993	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7423
p.T458M	DO231007	LUSC	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7423
p.L461I	DO48292	ESCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.6063
p.P459T	DO228971	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7031
p.T458K	DO229022	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.7306
p.P453Q	DO229026	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.25
p.P453T	DO229034	LICA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.25
p.K446Q	DO229227	THCA	ICGC	VSTPVLS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSB4	Keratin, type II cuticular Hb2	DEG_SCF_FBW7_1	456:462	VSTPVLS	FBXW7	0.7223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons