DegronMD - Q9NSC5(HOMER3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S159N	TCGA-06-5416	GBM	TCGA	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation blocking phosphorylation signal	0.5556
p.A160T	TCGA-37-4130	LUSC	TCGA	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1389
p.E169K	TCGA-39-5031	LUSC	TCGA	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.591
p.A170D	DO229035	LICA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7793
p.A183D	DO229041	LICA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1111
p.A174T	DO232224	PBCA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7139
p.A174T	DO41871	UCEC	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7139
p.A174T	DO41331	UCEC	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.7139
p.G165C	DO232185	RT	ICGC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.2778
p.E169V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6582
p.E169V	HT	haematopoietic and lymphoid tissue	COSMIC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6582
p.T166I	SIDM00025	Head and Neck Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.T166I	SIDM00881	Breast Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.T166I	SIDM00143	Small Cell Lung Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056
p.T166I	SIDM00123	Kidney Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.3056

Kaplan plot for HOMER3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOMER3

UniProt ID: Q9NSC5

Entrez ID: 9454

Protein name: Homer protein homolog 3 (Homer-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOMER3 in