DegronMD

Uniprot ID: Q9NSC5

Source protein: Homer protein homolog 3

Source gene: HOMER3

Class: DEG_APCC_DBOX_1

Location: 167:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9842

ASA_SCORE: 98.7111

COIL: 0.2409

CONS_SCORE: 0.7554

DSS_SCORE: 0.5934

HELIX: 0.7361

FCONS_SCORE: 1.1827

RIG_SCORE: 0.7454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S159N	TCGA-06-5416	GBM	TCGA	ERERLKKML	DEG_APCC_DBOX_1	0.5556
p.A160T	TCGA-37-4130	LUSC	TCGA	ERERLKKML	DEG_APCC_DBOX_1	0.1389
p.E169K	TCGA-39-5031	LUSC	TCGA	ERERLKKML	DEG_APCC_DBOX_1	0.591
p.A170D	DO229035	LICA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.7793
p.A183D	DO229041	LICA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.1111
p.A174T	DO232224	PBCA	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.7139
p.A174T	DO41871	UCEC	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.7139
p.A174T	DO41331	UCEC	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.7139
p.G165C	DO232185	RT	ICGC	ERERLKKML	DEG_APCC_DBOX_1	0.2778
p.E169V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	0.6582
p.E169V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	ERERLKKML	DEG_APCC_DBOX_1	0.6582
p.T166I	SIDM00025	Head and Neck Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	0.3056
p.T166I	SIDM00881	Breast Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	0.3056
p.T166I	SIDM00143	Small Cell Lung Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	0.3056
p.T166I	SIDM00123	Kidney Carcinoma	GDSC	ERERLKKML	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSC5	Homer protein homolog 3	DEG_APCC_DBOX_1	167:175	ERERLKKML	APC,CDC20,FZR1	0.9842	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons