DegronMD - Q9NSD9(FARSB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L62I	TCGA-AC-A23H	BRCA	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.L62I	DO2401	BRCA	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.R82Q	TCGA-AJ-A5DW	UCEC	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.R82Q	DO50075	UCEC	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.P68S	TCGA-EB-A430	SKCM	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.P68S	DO37906	SKCM	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.A69T	TCGA-EO-A22U	UCEC	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.A69T	DO43755	UCEC	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.V67I	TCGA-G9-6371	PRAD	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.25
p.V67I	DO36314	PRAD	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.25
p.D66H	TCGA-W3-A828	SKCM	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.D66H	DO51273	SKCM	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.N70D	TCGA-XE-AAOB	TGCT	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5821
p.R71T	DO71752	THCA	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.7876
p.G79V	SIDM00230	Small Cell Lung Carcinoma	GDSC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.G79V	ACH-002145	Lung Cancer	CCLE	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.G79V	IST-SL2	lung	COSMIC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.3056
p.L75M	SIDM00333	Endometrial Carcinoma	GDSC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5999
p.L75M	ACH-000988	Endometrial/Uterine Cancer	CCLE	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5999
p.L75M	MFE-319	endometrium	COSMIC	NRYDLLCLE	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5999

Kaplan plot for FARSB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FARSB

UniProt ID: Q9NSD9

Entrez ID: 10056

Protein name: Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FARSB in