DegronMD

Uniprot ID: Q9NSD9

Source protein: Phenylalanine--tRNA ligase beta subunit

Source gene: FARSB

Class: DEG_APCC_DBOX_1

Location: 70:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8826

ASA_SCORE: 23.1889

COIL: 0.6307

CONS_SCORE: 0.6813

DSS_SCORE: 0.022

HELIX: 0.34

FCONS_SCORE: 1.3076

RIG_SCORE: 0.9522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L62I	TCGA-AC-A23H	BRCA	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.1111
p.L62I	DO2401	BRCA	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.1111
p.R82Q	TCGA-AJ-A5DW	UCEC	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.2222
p.R82Q	DO50075	UCEC	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.2222
p.P68S	TCGA-EB-A430	SKCM	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.2778
p.P68S	DO37906	SKCM	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.2778
p.A69T	TCGA-EO-A22U	UCEC	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.3056
p.A69T	DO43755	UCEC	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.3056
p.V67I	TCGA-G9-6371	PRAD	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.25
p.V67I	DO36314	PRAD	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.25
p.D66H	TCGA-W3-A828	SKCM	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.2222
p.D66H	DO51273	SKCM	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.2222
p.N70D	TCGA-XE-AAOB	TGCT	TCGA	NRYDLLCLE	DEG_APCC_DBOX_1	0.5821
p.R71T	DO71752	THCA	ICGC	NRYDLLCLE	DEG_APCC_DBOX_1	0.7876
p.G79V	SIDM00230	Small Cell Lung Carcinoma	GDSC	NRYDLLCLE	DEG_APCC_DBOX_1	0.3056
p.G79V	ACH-002145	Lung Cancer	CCLE	NRYDLLCLE	DEG_APCC_DBOX_1	0.3056
p.G79V	IST-SL2	lung	COSMIC	NRYDLLCLE	DEG_APCC_DBOX_1	0.3056
p.L75M	SIDM00333	Endometrial Carcinoma	GDSC	NRYDLLCLE	DEG_APCC_DBOX_1	0.5999
p.L75M	ACH-000988	Endometrial/Uterine Cancer	CCLE	NRYDLLCLE	DEG_APCC_DBOX_1	0.5999
p.L75M	MFE-319	endometrium	COSMIC	NRYDLLCLE	DEG_APCC_DBOX_1	0.5999

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSD9	Phenylalanine--tRNA ligase beta subunit	DEG_APCC_DBOX_1	70:78	NRYDLLCLE	APC,CDC20,FZR1	0.8826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons