DegronMD - Q9NSE4(IARS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R817H	TCGA-AJ-A5DW	UCEC	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817H	TCGA-OL-A5S0	BRCA	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817H	DO44155	BRCA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817H	DO50075	UCEC	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817H	SIDM00192	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817H	SIDM01443	Gastric Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.F799L	TCGA-B5-A3FC	UCEC	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.2222
p.F799L	DO41871	UCEC	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.2222
p.D813Y	TCGA-EI-6917	READ	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.2222
p.D813Y	DO36881	READ	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.2222
p.R817C	DO228649	GACA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817C	SIDM00982	Glioblastoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R817C	42-MG-BA	central nervous system	COSMIC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1111
p.R816Q	DO233290	GACA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.1389
p.S800R	SIDM02029	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation rewiring degron network	0.25
p.D804N	SIDM00217	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation altering degron motif	0.5821
p.D804N	SNU-1040	large intestine	COSMIC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation altering degron motif	0.5821
p.D815Y	ACH-000997	Colon/Colorectal Cancer	CCLE	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation substituting flanking lysine	0.2778
p.D815Y	ACH-001061	Colon/Colorectal Cancer	CCLE	KDRLYCE	LIG_APCC_ABBAyCdc20_2	803:809	Mutation substituting flanking lysine	0.2778

Kaplan plot for IARS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IARS2

UniProt ID: Q9NSE4

Entrez ID: 55699

Protein name: Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IARS2 in