DegronMD

Uniprot ID: Q9NSE4

Source protein: Isoleucine--tRNA ligase, mitochondrial

Source gene: IARS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 803:809

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5615

ASA_SCORE: 82.3143

COIL: 0.5177

CONS_SCORE: 0.6872

DSS_SCORE: 0.0828

HELIX: 0.4036

FCONS_SCORE: 1.3033

RIG_SCORE: 0.9156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R817H	TCGA-AJ-A5DW	UCEC	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817H	TCGA-OL-A5S0	BRCA	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817H	DO44155	BRCA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817H	DO50075	UCEC	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817H	SIDM00192	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817H	SIDM01443	Gastric Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F799L	TCGA-B5-A3FC	UCEC	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.F799L	DO41871	UCEC	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D813Y	TCGA-EI-6917	READ	TCGA	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D813Y	DO36881	READ	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R817C	DO228649	GACA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817C	SIDM00982	Glioblastoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R817C	42-MG-BA	central_nervous_system	COSMIC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R816Q	DO233290	GACA	ICGC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S800R	SIDM02029	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.25
p.D804N	SIDM00217	Colorectal Carcinoma	GDSC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D804N	SNU-1040	large_intestine	COSMIC	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D815Y	ACH-000997	Colon/Colorectal Cancer	CCLE	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D815Y	ACH-001061	Colon/Colorectal Cancer	CCLE	KDRLYCE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSE4	Isoleucine--tRNA ligase, mitochondrial	LIG_APCC_ABBAyCdc20_2	803:809	KDRLYCE	APC,CDC20,FZR1	0.5615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons