DegronMD - Q9NSV4(DIAPH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N92T	TCGA-66-2770	LUSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5944
p.N92T	DO27556	LUSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5944
p.K94N	TCGA-77-7141	LUSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5806
p.K94N	TCGA-AP-A0LM	UCEC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5806
p.K94N	DO26450	LUSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5806
p.K94N	DO43306	UCEC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5806
p.P88H	TCGA-B5-A1MX	UCEC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6583
p.P88H	DO41999	UCEC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.6583
p.S103L	TCGA-CN-5369	HNSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.S103L	DO16069	HNSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0833
p.P88S	TCGA-FJ-A3ZE	BLCA	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5641
p.P88S	DO484	BLCA	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5641
p.A104S	TCGA-IB-7651	PAAD	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.A104S	DO46657	PAAD	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.N92Y	DO231655	LINC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation altering degron motif	0.5948
p.C102F	DO229232	THCA	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1111
p.V76L	HuH-7	liver	COSMIC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.0556
p.S79G	Daudi	haematopoietic and lymphoid tissue	COSMIC	ERPPLPNLK	DEG_APCC_DBOX_1	86:94	Mutation rewiring degron network	0.1389

Kaplan plot for DIAPH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIAPH3

UniProt ID: Q9NSV4

Entrez ID: 81624

Protein name: Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIAPH3 in