DegronMD

Uniprot ID: Q9NSV4

Source protein: Protein diaphanous homolog 3

Source gene: DIAPH3

Class: DEG_APCC_DBOX_1

Location: 86:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 104.2889

COIL: 0.9172

CONS_SCORE: 0.328

DSS_SCORE: 0.5548

HELIX: 0.0477

FCONS_SCORE: 1.1949

RIG_SCORE: 0.6698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N92T	TCGA-66-2770	LUSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.5944
p.N92T	DO27556	LUSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.5944
p.K94N	TCGA-77-7141	LUSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.5806
p.K94N	TCGA-AP-A0LM	UCEC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.5806
p.K94N	DO26450	LUSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.5806
p.K94N	DO43306	UCEC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.5806
p.P88H	TCGA-B5-A1MX	UCEC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.6583
p.P88H	DO41999	UCEC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.6583
p.S103L	TCGA-CN-5369	HNSC	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.0833
p.S103L	DO16069	HNSC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.0833
p.P88S	TCGA-FJ-A3ZE	BLCA	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.5641
p.P88S	DO484	BLCA	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.5641
p.A104S	TCGA-IB-7651	PAAD	TCGA	ERPPLPNLK	DEG_APCC_DBOX_1	0.0556
p.A104S	DO46657	PAAD	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.0556
p.N92Y	DO231655	LINC	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.5948
p.C102F	DO229232	THCA	ICGC	ERPPLPNLK	DEG_APCC_DBOX_1	0.1111
p.V76L	HuH-7	liver	COSMIC	ERPPLPNLK	DEG_APCC_DBOX_1	0.0556
p.S79G	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ERPPLPNLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSV4	Protein diaphanous homolog 3	DEG_APCC_DBOX_1	86:94	ERPPLPNLK	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons