DegronMD - Q9NT99(LRRC4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M391K	TCGA-44-7661	LUAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1667
p.M391K	DO23602	LUAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1667
p.V394G	TCGA-60-2724	LUSC	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.25
p.V394G	DO26540	LUSC	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.25
p.A530V	TCGA-66-2756	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.A530V	DO27128	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.A530V	DO232224	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.R410L	TCGA-86-A456	LUAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1111
p.R410L	DO24890	LUAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1111
p.P399H	TCGA-92-8063	LUSC	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.7694
p.P399H	DO26941	LUSC	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.7694
p.V411M	TCGA-BS-A0WQ	UCEC	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.0833
p.V411M	DO42705	UCEC	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.0833
p.T398M	TCGA-CK-6747	COAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.7423
p.T398M	DO10156	COAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.7423
p.P543Q	TCGA-CV-7415	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543Q	TCGA-ER-A196	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543Q	DO14926	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543Q	DO47474	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.S408F	TCGA-DA-A3F8	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1667
p.S408F	DO37418	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1667
p.P543S	TCGA-EE-A2MM	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	DO222678	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	DO37770	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	SIDM00319	Melanoma	GDSC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	ACH-001704	Skin Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.P543S	VMRC-MELG	skin	COSMIC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1667
p.R410S	TCGA-EE-A3AB	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1111
p.R410S	DO38057	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1111
p.G401C	TCGA-ER-A19P	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.6489
p.G401C	DO47623	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.6489
p.M404T	TCGA-EY-A1GU	UCEC	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.2778
p.M404T	DO41518	UCEC	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.2778
p.G401S	TCGA-HU-A4GX	STAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.5882
p.G401S	DO47757	STAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation altering degron motif	0.5882
p.R547Q	TCGA-V3-A9ZY	UVM	TCGA	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0556
p.V394I	DO888	BOCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.25
p.H406N	DO224987	BRCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.2222
p.S546P	DO222637	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.R544H	DO229389	BTCA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1389
p.R544H	SIDM00596	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1389
p.R544H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1389
p.R544H	HEC-1	endometrium	COSMIC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1389
p.G388D	DO227522	COCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.0833
p.G388V	DO233105	GACA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.0833
p.G388V	DO232224	PBCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.0833
p.R410C	DO233843	GACA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1111
p.G528E	DO222409	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.1944
p.T539M	DO50686	ORCA	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2778
p.T539M	ACH-001229	Primary	CCLE	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.2778
p.G407S	DO232067	ORCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	397:402	Mutation rewiring degron network	0.1944
p.A530T	DO46331	OV	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.R547W	DO230502	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0556
p.A540P	SIDM01107	Melanoma	GDSC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.A540P	SK-MEL-1	skin	COSMIC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.25
p.S546L	SIDM01619	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.S546L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.0833
p.G532D	ACH-002396	Bone Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.3056
p.G532D	Sarc9371	bone	COSMIC	PASSS	DEG_SPOP_SBC_1	533:537	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC4B

UniProt ID: Q9NT99

Entrez ID: 94030

Protein name: Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC4B in