DegronMD

Uniprot ID: Q9NT99

Source protein: Leucine-rich repeat-containing protein 4B

Source gene: LRRC4B

Class: DEG_SCF_FBW7_1

Location: 397:402

E3 ligase: FBXW7

DEGRON score: 0.9814

ASA_SCORE: 55.8667

COIL: 0.768

CONS_SCORE: 0.7251

DSS_SCORE: 0.3379

HELIX: 0.004

FCONS_SCORE: 1.194

RIG_SCORE: 0.7883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M391K	TCGA-44-7661	LUAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.1667
p.M391K	DO23602	LUAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1667
p.V394G	TCGA-60-2724	LUSC	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.25
p.V394G	DO26540	LUSC	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.25
p.R410L	TCGA-86-A456	LUAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.1111
p.R410L	DO24890	LUAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1111
p.P399H	TCGA-92-8063	LUSC	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.7694
p.P399H	DO26941	LUSC	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.7694
p.V411M	TCGA-BS-A0WQ	UCEC	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.0833
p.V411M	DO42705	UCEC	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.0833
p.T398M	TCGA-CK-6747	COAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.7423
p.T398M	DO10156	COAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.7423
p.S408F	TCGA-DA-A3F8	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.1667
p.S408F	DO37418	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1667
p.R410S	TCGA-EE-A3AB	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.1111
p.R410S	DO38057	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1111
p.G401C	TCGA-ER-A19P	SKCM	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.6489
p.G401C	DO47623	SKCM	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.6489
p.M404T	TCGA-EY-A1GU	UCEC	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.2778
p.M404T	DO41518	UCEC	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.2778
p.G401S	TCGA-HU-A4GX	STAD	TCGA	LTPNGT	DEG_SCF_FBW7_1	0.5882
p.G401S	DO47757	STAD	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.5882
p.V394I	DO888	BOCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.25
p.H406N	DO224987	BRCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.2222
p.G388D	DO227522	COCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.0833
p.G388V	DO233105	GACA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.0833
p.G388V	DO232224	PBCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.0833
p.R410C	DO233843	GACA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1111
p.G407S	DO232067	ORCA	ICGC	LTPNGT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NT99	Leucine-rich repeat-containing protein 4B	DEG_SCF_FBW7_1	397:402	LTPNGT	FBXW7	0.9814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPNGT

Degron related mutations and impact score

Drug responses associated with LRRC4B mutations

All proteins holding degron of LTPNGT