DegronMD - Q9NUG4(CCM2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C30G	TCGA-35-4122	LUAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.C30G	DO23782	LUAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.P38H	TCGA-46-3769	LUSC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6583
p.P38H	DO26590	LUSC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6583
p.P38T	TCGA-50-5930	LUAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5919
p.P38T	DO25189	LUAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5919
p.R36C	TCGA-5P-A9K6	KIRP	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8301
p.R36C	DO223950	KIRP	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8301
p.R36C	ACH-000901	Lung Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8301
p.D48N	TCGA-63-A5MW	LUSC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.D48N	DO219169	LUSC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R26H	TCGA-D1-A103	UCEC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.R26H	DO42312	UCEC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.H40Y	TCGA-G2-A2ES	BLCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6118
p.H40Y	DO785	BLCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6118
p.R36H	TCGA-G4-6307	COAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	TCGA-L5-A4OF	ESCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	DO9650	COAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	DO35668	PBCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	SIDM00386	Ewing's Sarcoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	ACH-000391	Bone Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	MHH-ES-1	bone	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.P53L	TCGA-G4-6586	COAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.P53L	DO9698	COAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R37W	DO233203	GACA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7523
p.R27Q	DO233882	GACA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	SIDM00943	Pancreatic Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	SIDM00673	Breast Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	ACH-000107	Pancreatic Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	ACH-000668	Breast Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	ACH-000781	Lung Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	ACH-002264	Esophageal Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	Capan-2	pancreas	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	KYSE-50	oesophagus	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	NCI-H2023	lung	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R27Q	HCC70	breast	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.M42I	DO229018	LICA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6507
p.R27W	DO220881	MELA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1111
p.R26C	DO46372	OV	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.R26C	DO47116	RECA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.P38S	SIDM00781	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5641
p.P38S	SIDM00780	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5641
p.P38S	ACH-000967	Colon/Colorectal Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5641
p.P38S	SNU-C2B	large intestine	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5641
p.D52N	SIDM00829	Acute Myeloid Leukemia	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.D52N	ACH-000002	Leukemia	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.D52N	HL-60	haematopoietic and lymphoid tissue	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.S33R	SIDM00818	Kidney Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation blocking phosphorylation signal	0.7222
p.S33R	RCC-JF	kidney	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation blocking phosphorylation signal	0.7222
p.P46L	SIDM00853	Other Sarcomas	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.P46L	ACH-000835	Sarcoma	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.P46L	GCT	soft tissue	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCM2L

UniProt ID: Q9NUG4

Entrez ID: 140706

Protein name: Cerebral cavernous malformations 2 protein-like (CCM2-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCM2L in