DegronMD

Uniprot ID: Q9NUG4

Source protein: Cerebral cavernous malformations 2 protein-like

Source gene: CCM2L

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9175

ASA_SCORE: 76.6778

COIL: 0.7202

CONS_SCORE: 0.7395

DSS_SCORE: 0.2878

HELIX: 0.0243

FCONS_SCORE: 1.2206

RIG_SCORE: 0.6921

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R36C	TCGA-5P-A9K6	KIRP	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.R36C	DO223950	KIRP	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.R36C	ACH-000901	Lung Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.R36H	TCGA-G4-6307	COAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	TCGA-L5-A4OF	ESCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO9650	COAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO35668	PBCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	SIDM00386	Ewing's Sarcoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	ACH-000391	Bone Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	MHH-ES-1	bone	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R37W	DO233203	GACA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7523
p.S33R	SIDM00818	Kidney Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7222
p.S33R	RCC-JF	kidney	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7222
p.P38H	TCGA-46-3769	LUSC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.6583
p.P38H	DO26590	LUSC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6583
p.M42I	DO229018	LICA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6507
p.H40Y	TCGA-G2-A2ES	BLCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.6118
p.H40Y	DO785	BLCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6118
p.P38T	TCGA-50-5930	LUAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.5919
p.P38T	DO25189	LUAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5919
p.P38S	SIDM00781	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	SIDM00780	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	ACH-000967	Colon/Colorectal Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	SNU-C2B	large_intestine	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P46L	SIDM00853	Other Sarcomas	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.25

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Drug responses associated with CCM2L mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of SRRPLHSMP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUG4	Cerebral cavernous malformations 2 protein-like	DEG_APCC_DBOX_1	35:43	SRRPLHSMP	APC,CDC20,FZR1	0.9175	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRPLHSMP

Degron related mutations and impact score

Drug responses associated with CCM2L mutations

All proteins holding degron of SRRPLHSMP