DegronMD

Uniprot ID: Q9NUG4

Source protein: Cerebral cavernous malformations 2 protein-like

Source gene: CCM2L

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9175

ASA_SCORE: 76.6778

COIL: 0.7202

CONS_SCORE: 0.7395

DSS_SCORE: 0.2878

HELIX: 0.0243

FCONS_SCORE: 1.2206

RIG_SCORE: 0.6921

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C30G	TCGA-35-4122	LUAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.1944
p.C30G	DO23782	LUAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1944
p.P38H	TCGA-46-3769	LUSC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.6583
p.P38H	DO26590	LUSC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6583
p.P38T	TCGA-50-5930	LUAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.5919
p.P38T	DO25189	LUAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5919
p.R36C	TCGA-5P-A9K6	KIRP	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.R36C	DO223950	KIRP	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.R36C	ACH-000901	Lung Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.8301
p.D48N	TCGA-63-A5MW	LUSC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.1944
p.D48N	DO219169	LUSC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1944
p.R26H	TCGA-D1-A103	UCEC	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.R26H	DO42312	UCEC	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.H40Y	TCGA-G2-A2ES	BLCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.6118
p.H40Y	DO785	BLCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6118
p.R36H	TCGA-G4-6307	COAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	TCGA-L5-A4OF	ESCA	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO9650	COAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO35668	PBCA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	SIDM00386	Ewing's Sarcoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	ACH-000391	Bone Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.R36H	MHH-ES-1	bone	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.8244
p.P53L	TCGA-G4-6586	COAD	TCGA	SRRPLHSMP	DEG_APCC_DBOX_1	0.0556
p.P53L	DO9698	COAD	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0556
p.R37W	DO233203	GACA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7523
p.R27Q	DO233882	GACA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	SIDM00943	Pancreatic Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	SIDM00673	Breast Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	ACH-000107	Pancreatic Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	ACH-000668	Breast Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	ACH-000781	Lung Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	ACH-002264	Esophageal Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	Capan-2	pancreas	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	KYSE-50	oesophagus	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	NCI-H2023	lung	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R27Q	HCC70	breast	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.M42I	DO229018	LICA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.6507
p.R27W	DO220881	MELA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.1111
p.R26C	DO46372	OV	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.R26C	DO47116	RECA	ICGC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.P38S	SIDM00781	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	SIDM00780	Colorectal Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	ACH-000967	Colon/Colorectal Cancer	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.P38S	SNU-C2B	large_intestine	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.5641
p.D52N	SIDM00829	Acute Myeloid Leukemia	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.D52N	ACH-000002	Leukemia	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.D52N	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.0833
p.S33R	SIDM00818	Kidney Carcinoma	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7222
p.S33R	RCC-JF	kidney	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.7222
p.P46L	SIDM00853	Other Sarcomas	GDSC	SRRPLHSMP	DEG_APCC_DBOX_1	0.25
p.P46L	ACH-000835	Sarcoma	CCLE	SRRPLHSMP	DEG_APCC_DBOX_1	0.25
p.P46L	GCT	soft_tissue	COSMIC	SRRPLHSMP	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRRPLHSMP

Degron related mutations and impact score

Drug responses associated with CCM2L mutations

All proteins holding degron of SRRPLHSMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUG4	Cerebral cavernous malformations 2 protein-like	DEG_APCC_DBOX_1	35:43	SRRPLHSMP	APC,CDC20,FZR1	0.9175	More...