DegronMD - Q9NUL7(DDX28)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R520C	TCGA-58-8386	LUSC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	TCGA-A5-A0G2	UCEC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	DO45537	LUSC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	DO41235	UCEC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	SIDM00516	Melanoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	ACH-002166	Skin Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.R520C	MZ7-mel	skin	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.3056
p.S524N	TCGA-AX-A1CE	UCEC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7069
p.S524N	DO42280	UCEC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7069
p.A518V	TCGA-EI-6513	READ	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.25
p.A518V	DO37372	READ	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.25
p.V532M	DO50970	LICA	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.25
p.R521Q	DO52151	PAEN	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.6218
p.L517V	SIDM00596	Endometrial Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2222
p.L517V	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2222
p.L517V	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2222
p.L517V	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2222
p.L517V	HEC-1	endometrium	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2222
p.L525I	SIDM01081	Oral Cavity Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7174
p.L525I	ACH-000238	Head and Neck Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7174
p.L525I	SCC-4	upper aerodigestive tract	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation altering degron motif	0.7174
p.S531L	SIDM00664	Pancreatic Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2778
p.S531L	ACH-000178	Pancreatic Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2778
p.S531L	Hs766T	pancreas	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation rewiring degron network	0.2778
p.K514N	SIDM01611	Endometrial Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation substituting flanking lysine	0.25
p.K514N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	521:529	Mutation substituting flanking lysine	0.25

Kaplan plot for DDX28 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDX28

UniProt ID: Q9NUL7

Entrez ID: 55794

Protein name: Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DDX28 in