DegronMD

Uniprot ID: Q9NUL7

Source protein: Probable ATP-dependent RNA helicase DDX28

Source gene: DDX28

Class: DEG_APCC_DBOX_1

Location: 521:529

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9577

ASA_SCORE: 86.9889

COIL: 0.9236

CONS_SCORE: 0.3577

DSS_SCORE: 0.3639

HELIX: 0.0306

FCONS_SCORE: 0.918

RIG_SCORE: 0.7082

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R520C	TCGA-58-8386	LUSC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	TCGA-A5-A0G2	UCEC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	DO45537	LUSC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	DO41235	UCEC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	SIDM00516	Melanoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	ACH-002166	Skin Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.R520C	MZ7-mel	skin	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	0.3056
p.S524N	TCGA-AX-A1CE	UCEC	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	0.7069
p.S524N	DO42280	UCEC	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.7069
p.A518V	TCGA-EI-6513	READ	TCGA	RRRSLPGLA	DEG_APCC_DBOX_1	0.25
p.A518V	DO37372	READ	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.25
p.V532M	DO50970	LICA	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.25
p.R521Q	DO52151	PAEN	ICGC	RRRSLPGLA	DEG_APCC_DBOX_1	0.6218
p.L517V	SIDM00596	Endometrial Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	0.2222
p.L517V	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.2222
p.L517V	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.2222
p.L517V	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.2222
p.L517V	HEC-1	endometrium	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	0.2222
p.L525I	SIDM01081	Oral Cavity Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	0.7174
p.L525I	ACH-000238	Head and Neck Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.7174
p.L525I	SCC-4	upper_aerodigestive_tract	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	0.7174
p.S531L	SIDM00664	Pancreatic Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	0.2778
p.S531L	ACH-000178	Pancreatic Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.2778
p.S531L	Hs766T	pancreas	COSMIC	RRRSLPGLA	DEG_APCC_DBOX_1	0.2778
p.K514N	SIDM01611	Endometrial Carcinoma	GDSC	RRRSLPGLA	DEG_APCC_DBOX_1	0.25
p.K514N	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRRSLPGLA	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLPGLA

Degron related mutations and impact score

Drug responses associated with DDX28 mutations

All proteins holding degron of RRRSLPGLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUL7	Probable ATP-dependent RNA helicase DDX28	DEG_APCC_DBOX_1	521:529	RRRSLPGLA	APC,CDC20,FZR1	0.9577	More...