DegronMD - Q9NUR3(TMEM74B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V115M	DO230336	COCA	ICGC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1111
p.V115L	DO230950	LUSC	ICGC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1111
p.V115L	DO224638	LUSC	ICGC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1111
p.P110R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.25
p.P110R	ACH-002263	Esophageal Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.25
p.P110R	KYSE-220	oesophagus	COSMIC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.25
p.P114A	SIDM00333	Endometrial Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1389
p.P114A	ACH-000988	Endometrial/Uterine Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1389
p.P114A	MFE-319	endometrium	COSMIC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.1389
p.D100N	SIDM01228	Melanoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.2778
p.D100N	ACH-001024	Skin Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.2778
p.D100N	CHL-1	skin	COSMIC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation rewiring degron network	0.2778
p.S103P	SIDM01611	Endometrial Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation altering degron motif	0.5641
p.S103P	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	102:107	Mutation altering degron motif	0.5641

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons