DegronMD

Uniprot ID: Q9NUR3

Source protein: Transmembrane protein 74B

Source gene: TMEM74B

Class: LIG_APCC_ABBA_1

Location: 102:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 78.2333

COIL: 0.8365

CONS_SCORE: 0.6106

DSS_SCORE: 0.6289

HELIX: 0.1157

FCONS_SCORE: 1.3121

RIG_SCORE: 0.6503

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S103P	SIDM01611	Endometrial Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	0.5641
p.S103P	ACH-000996	Endometrial/Uterine Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	0.5641
p.D100N	SIDM01228	Melanoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	0.2778
p.D100N	ACH-001024	Skin Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	0.2778
p.D100N	CHL-1	skin	COSMIC	LSLHSE	LIG_APCC_ABBA_1	0.2778
p.P110R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	0.25
p.P110R	ACH-002263	Esophageal Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	0.25
p.P110R	KYSE-220	oesophagus	COSMIC	LSLHSE	LIG_APCC_ABBA_1	0.25
p.P114A	SIDM00333	Endometrial Carcinoma	GDSC	LSLHSE	LIG_APCC_ABBA_1	0.1389
p.P114A	ACH-000988	Endometrial/Uterine Cancer	CCLE	LSLHSE	LIG_APCC_ABBA_1	0.1389
p.P114A	MFE-319	endometrium	COSMIC	LSLHSE	LIG_APCC_ABBA_1	0.1389
p.V115M	DO230336	COCA	ICGC	LSLHSE	LIG_APCC_ABBA_1	0.1111
p.V115L	DO230950	LUSC	ICGC	LSLHSE	LIG_APCC_ABBA_1	0.1111
p.V115L	DO224638	LUSC	ICGC	LSLHSE	LIG_APCC_ABBA_1	0.1111

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUR3	Transmembrane protein 74B	LIG_APCC_ABBA_1	102:107	LSLHSE	APC,CDC20,FZR1	0.999	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons