DegronMD - Q9NUV9(GIMAP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P12H	TCGA-BF-A1PZ	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7694
p.P12H	TCGA-EM-A22L	THCA	TCGA	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7694
p.P12H	DO50279	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7694
p.P12H	DO38923	THCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7694
p.G20R	TCGA-FR-A8YC	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.G22E	TCGA-FR-A8YC	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2222
p.N28Y	TCGA-W3-AA1V	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.E21Q	DO1301	BRCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.25
p.S13N	DO230312	COCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.5958
p.Y5C	DO222874	COCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1389
p.A23E	DO24739	LUAD	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1944
p.S25N	DO37406	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1389
p.S25R	DO37406	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1389
p.G20S	DO50301	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.Q28H	DO41644	UCEC	ICGC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.Q28H	SIDM00795	Melanoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.Q28H	A375	skin	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.0556
p.R22M	SIDM00663	Melanoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2222
p.G6R	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1667
p.G6R	ACH-002176	Lung Cancer	CCLE	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1667
p.G6R	NCI-H748	lung	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.1667
p.R22W	SIDM00120	Prostate Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2222
p.R22W	DU-145	prostate	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2222
p.F10L	SIDM00963	Breast Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.F10L	ACH-000927	Breast Cancer	CCLE	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.F10L	BT-474	breast	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation rewiring degron network	0.2778
p.P15A	ACH-001020	Rhabdoid	CCLE	PSTPGAS	DEG_SCF_FBW7_1	12:18	Mutation altering degron motif	0.7503

Kaplan plot for GIMAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GIMAP4

UniProt ID: Q9NUV9

Entrez ID: 55303

Protein name: GTPase IMAP family member 4 (Immunity-associated nucleotide 1 protein) (IAN-1) (hIAN1) (Immunity-associated protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GIMAP4 in