DegronMD

Uniprot ID: Q9NUV9

Source protein: GTPase IMAP family member 4

Source gene: GIMAP4

Class: DEG_SCF_FBW7_1

Location: 12:18

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 74.0857

COIL: 0.9419

CONS_SCORE: 0.4061

DSS_SCORE: 0.617

HELIX: 0.021

FCONS_SCORE: 0.9687

RIG_SCORE: 0.5913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P12H	TCGA-BF-A1PZ	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	0.7694
p.P12H	TCGA-EM-A22L	THCA	TCGA	PSTPGAS	DEG_SCF_FBW7_1	0.7694
p.P12H	DO50279	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.7694
p.P12H	DO38923	THCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.7694
p.G20R	TCGA-FR-A8YC	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	0.2778
p.G22E	TCGA-FR-A8YC	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	0.2222
p.N28Y	TCGA-W3-AA1V	SKCM	TCGA	PSTPGAS	DEG_SCF_FBW7_1	0.0556
p.E21Q	DO1301	BRCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.25
p.S13N	DO230312	COCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.5958
p.Y5C	DO222874	COCA	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.1389
p.A23E	DO24739	LUAD	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.1944
p.S25N	DO37406	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.1389
p.S25R	DO37406	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.1389
p.G20S	DO50301	SKCM	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.2778
p.Q28H	DO41644	UCEC	ICGC	PSTPGAS	DEG_SCF_FBW7_1	0.0556
p.Q28H	SIDM00795	Melanoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	0.0556
p.Q28H	A375	skin	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	0.0556
p.R22M	SIDM00663	Melanoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	0.2222
p.G6R	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	0.1667
p.G6R	ACH-002176	Lung Cancer	CCLE	PSTPGAS	DEG_SCF_FBW7_1	0.1667
p.G6R	NCI-H748	lung	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	0.1667
p.R22W	SIDM00120	Prostate Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	0.2222
p.R22W	DU-145	prostate	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	0.2222
p.F10L	SIDM00963	Breast Carcinoma	GDSC	PSTPGAS	DEG_SCF_FBW7_1	0.2778
p.F10L	ACH-000927	Breast Cancer	CCLE	PSTPGAS	DEG_SCF_FBW7_1	0.2778
p.F10L	BT-474	breast	COSMIC	PSTPGAS	DEG_SCF_FBW7_1	0.2778
p.P15A	ACH-001020	Rhabdoid	CCLE	PSTPGAS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NUV9	GTPase IMAP family member 4	DEG_SCF_FBW7_1	12:18	PSTPGAS	FBXW7	0.9941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPGAS

Degron related mutations and impact score

Drug responses associated with GIMAP4 mutations

All proteins holding degron of PSTPGAS