DegronMD - Q9NV58(RNF19A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V494A	TCGA-2Z-A9J5	KIRP	TCGA	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.V494A	DO219654	KIRP	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488T	TCGA-B5-A1MX	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488T	DO41999	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488T	SIDM00217	Colorectal Carcinoma	GDSC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488T	ACH-000999	Colon/Colorectal Cancer	CCLE	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488T	SNU-1040	large intestine	COSMIC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.T492A	TCGA-CV-6937	HNSC	TCGA	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7139
p.T492A	DO14155	HNSC	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7139
p.I480V	TCGA-E7-A85H	BLCA	TCGA	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.0833
p.I480V	DO219018	BLCA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.0833
p.A488S	TCGA-FI-A2D5	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.A488S	DO41331	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.I480M	DO230326	COCA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.0833
p.D490E	DO229022	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.5647
p.T487K	DO229024	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.H499N	DO229037	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.S502N	DO232761	PBCA	ICGC	VDTTS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.0833

Kaplan plot for RNF19A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF19A

UniProt ID: Q9NV58

Entrez ID: 25897

Protein name: E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF19A in