DegronMD

Uniprot ID: Q9NV58

Source protein: E3 ubiquitin-protein ligase RNF19A

Source gene: RNF19A

Class: DEG_SPOP_SBC_1

Location: 489:493

E3 ligase: SPOP

DEGRON score: 0.6051

ASA_SCORE: 70.46

COIL: 0.6344

CONS_SCORE: 0.2645

DSS_SCORE: 0.5282

HELIX: 0.3138

FCONS_SCORE: 1.0383

RIG_SCORE: 0.8059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V494A	TCGA-2Z-A9J5	KIRP	TCGA	VDTTS	DEG_SPOP_SBC_1	0.3056
p.V494A	DO219654	KIRP	ICGC	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488T	TCGA-B5-A1MX	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488T	DO41999	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488T	SIDM00217	Colorectal Carcinoma	GDSC	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488T	ACH-000999	Colon/Colorectal Cancer	CCLE	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488T	SNU-1040	large_intestine	COSMIC	VDTTS	DEG_SPOP_SBC_1	0.3056
p.T492A	TCGA-CV-6937	HNSC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.7139
p.T492A	DO14155	HNSC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.7139
p.I480V	TCGA-E7-A85H	BLCA	TCGA	VDTTS	DEG_SPOP_SBC_1	0.0833
p.I480V	DO219018	BLCA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.0833
p.A488S	TCGA-FI-A2D5	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.3056
p.A488S	DO41331	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.3056
p.I480M	DO230326	COCA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.0833
p.D490E	DO229022	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.5647
p.T487K	DO229024	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.2778
p.H499N	DO229037	LICA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.1667
p.S502N	DO232761	PBCA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	18:22	VDTTS	SPOP	0.8307	More...
Q9NV58	E3 ubiquitin-protein ligase RNF19A	DEG_SPOP_SBC_1	489:493	VDTTS	SPOP	0.6051	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2191:2195	VDTTS	SPOP	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons