DegronMD

Uniprot ID: Q86XQ3

Source protein: Cation channel sperm-associated protein 3

Source gene: CATSPER3

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.8307

ASA_SCORE: 80.96

COIL: 0.8696

CONS_SCORE: 0.412

DSS_SCORE: 0.3276

HELIX: 0.0922

FCONS_SCORE: 1.0263

RIG_SCORE: 0.6952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V18A	TCGA-05-4396	LUAD	TCGA	VDTTS	DEG_SPOP_SBC_1	0.5825
p.V18A	TCGA-BR-6452	STAD	TCGA	VDTTS	DEG_SPOP_SBC_1	0.5825
p.V18A	DO23838	LUAD	ICGC	VDTTS	DEG_SPOP_SBC_1	0.5825
p.V18A	DO38404	STAD	ICGC	VDTTS	DEG_SPOP_SBC_1	0.5825
p.S22L	TCGA-A5-A0G1	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.7667
p.S22L	DO42472	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.7667
p.S22L	SIDM01205	Acute Myeloid Leukemia	GDSC	VDTTS	DEG_SPOP_SBC_1	0.7667
p.S22L	SIDM01195	Acute Myeloid Leukemia	GDSC	VDTTS	DEG_SPOP_SBC_1	0.7667
p.K30N	TCGA-AN-A046	BRCA	TCGA	VDTTS	DEG_SPOP_SBC_1	0.2222
p.K30N	DO1285	BRCA	ICGC	VDTTS	DEG_SPOP_SBC_1	0.2222
p.R11I	TCGA-EO-A22R	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.1389
p.R11I	DO42713	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.1389
p.R8H	TCGA-EO-A3AY	UCEC	TCGA	VDTTS	DEG_SPOP_SBC_1	0.0556
p.R8H	DO43202	UCEC	ICGC	VDTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XQ3	Cation channel sperm-associated protein 3	DEG_SPOP_SBC_1	18:22	VDTTS	SPOP	0.8307	More...
Q9NV58	E3 ubiquitin-protein ligase RNF19A	DEG_SPOP_SBC_1	489:493	VDTTS	SPOP	0.6051	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2191:2195	VDTTS	SPOP	0.9109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons