DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VDTTS
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_SPOP_SBC_1
Location:
2191:2195
E3 ligase:
SPOP
DEGRON score:
0.9109
ASA_SCORE:
76.3
COIL:
0.5808
CONS_SCORE:
0
DSS_SCORE:
0.3703
HELIX:
0.036
FCONS_SCORE:
0
RIG_SCORE:
0.7582
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VDTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86XQ3
Cation channel sperm-associated protein 3
DEG_SPOP_SBC_1
18:22
VDTTS
SPOP
0.8307
More...
Q9NV58
E3 ubiquitin-protein ligase RNF19A
DEG_SPOP_SBC_1
489:493
VDTTS
SPOP
0.6051
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2191:2195
VDTTS
SPOP
0.9109
More...