DegronMD - Q9NV64(TMEM39A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N31Y	TCGA-23-1021	OV	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.N31Y	DO32183	OV	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0833
p.R6S	TCGA-95-7947	LUAD	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.R6S	DO26404	LUAD	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.A17T	TCGA-AA-A010	COAD	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6028
p.L18S	TCGA-DI-A1BU	UCEC	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7667
p.L18S	DO42023	UCEC	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7667
p.S20Y	TCGA-EO-A3AY	UCEC	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6009
p.S20Y	DO43202	UCEC	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6009
p.G7D	DO233190	GACA	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1389
p.R15S	DO229045	LICA	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7427
p.R15H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8244
p.R15H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8244
p.R15H	ACH-000995	Leukemia	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8244
p.R15H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.8244
p.T23A	SIDM01045	Endometrial Carcinoma	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.T23A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.T23A	EN	endometrium	COSMIC	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.S16L	ACH-000975	Lung Cancer	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6556

Kaplan plot for TMEM39A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM39A

UniProt ID: Q9NV64

Entrez ID: 55254

Protein name: Transmembrane protein 39A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM39A in