DegronMD

Uniprot ID: Q9NV64

Source protein: Transmembrane protein 39A

Source gene: TMEM39A

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9296

ASA_SCORE: 91.7778

COIL: 0.819

CONS_SCORE: 0.3426

DSS_SCORE: 0.6183

HELIX: 0.15

FCONS_SCORE: 0.9567

RIG_SCORE: 0.6999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N31Y	TCGA-23-1021	OV	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	0.0833
p.N31Y	DO32183	OV	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.0833
p.R6S	TCGA-95-7947	LUAD	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	0.1111
p.R6S	DO26404	LUAD	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.1111
p.A17T	TCGA-AA-A010	COAD	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	0.6028
p.L18S	TCGA-DI-A1BU	UCEC	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	0.7667
p.L18S	DO42023	UCEC	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.7667
p.S20Y	TCGA-EO-A3AY	UCEC	TCGA	SRSALPSLQ	DEG_APCC_DBOX_1	0.6009
p.S20Y	DO43202	UCEC	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.6009
p.G7D	DO233190	GACA	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.1389
p.R15S	DO229045	LICA	ICGC	SRSALPSLQ	DEG_APCC_DBOX_1	0.7427
p.R15H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	0.8244
p.R15H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	0.8244
p.R15H	ACH-000995	Leukemia	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	0.8244
p.R15H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	SRSALPSLQ	DEG_APCC_DBOX_1	0.8244
p.T23A	SIDM01045	Endometrial Carcinoma	GDSC	SRSALPSLQ	DEG_APCC_DBOX_1	0.3056
p.T23A	ACH-000978	Endometrial/Uterine Cancer	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	0.3056
p.T23A	EN	endometrium	COSMIC	SRSALPSLQ	DEG_APCC_DBOX_1	0.3056
p.S16L	ACH-000975	Lung Cancer	CCLE	SRSALPSLQ	DEG_APCC_DBOX_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NV64	Transmembrane protein 39A	DEG_APCC_DBOX_1	14:22	SRSALPSLQ	APC,CDC20,FZR1	0.9296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons