DegronMD - Q9NV66(TYW1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K694R	TCGA-33-4586	LUSC	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking ubiquitination signal	0.6667
p.K694R	DO27318	LUSC	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking ubiquitination signal	0.6667
p.S692C	TCGA-44-8117	LUAD	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.S692C	DO24028	LUAD	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.D695N	TCGA-A5-A0G2	UCEC	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.1944
p.D695N	DO41235	UCEC	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.1944
p.L678I	TCGA-AA-3966	COAD	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.1667
p.L678I	DO10068	COAD	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.1667
p.F691C	TCGA-AO-A0J8	BRCA	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.3056
p.F691C	DO2909	BRCA	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.3056
p.A693T	TCGA-AP-A056	UCEC	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.25
p.A693T	DO43971	UCEC	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.25
p.R674H	TCGA-AP-A059	UCEC	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.0556
p.R674H	DO41361	UCEC	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.0556
p.E681D	TCGA-CA-6717	COAD	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.25
p.E681D	DO8264	COAD	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.25
p.S692N	TCGA-HU-A4GT	STAD	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.S692N	DO48020	STAD	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.S692N	SIDM01169	Ovarian Carcinoma	GDSC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.S692N	ACH-000885	Ovarian Cancer	CCLE	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.S692N	TOV-21G	ovary	COSMIC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation blocking phosphorylation signal	0.7222
p.G686C	TCGA-SJ-A6ZI	UCEC	TCGA	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation altering degron motif	0.76
p.G686C	DO219784	UCEC	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation altering degron motif	0.76
p.A698T	DO232224	PBCA	ICGC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.1111
p.D684G	SIDM00957	Colorectal Carcinoma	GDSC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation altering degron motif	0.7198
p.D684G	ACH-000350	Colon/Colorectal Cancer	CCLE	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation altering degron motif	0.7198
p.D684G	COLO-678	large intestine	COSMIC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation altering degron motif	0.7198
p.T700I	SIDM00177	Melanoma	GDSC	DSGGSKT	DEG_SCF_TRCP1_1	684:690	Mutation rewiring degron network	0.0556

Kaplan plot for TYW1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TYW1

UniProt ID: Q9NV66

Entrez ID: 55253

Protein name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 1) (tRNA wybutosine-synthesizing protein 1 homolog) (tRNA-yW-synthesizing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TYW1 in