DegronMD - Q9NV96(TMEM30A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R133H	TCGA-AJ-A3EK	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.8244
p.R133H	TCGA-B5-A3FA	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.8244
p.V135M	TCGA-DD-AACN	LIHC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.3056
p.N144H	TCGA-E6-A1LX	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.0556
p.G116C	TCGA-EB-A299	SKCM	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.1667
p.G116C	TCGA-ER-A19B	SKCM	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.1667
p.K112M	TCGA-MH-A561	KIRP	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation substituting flanking lysine	0.1667
p.K112M	DO48509	KIRP	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation substituting flanking lysine	0.1667
p.P131T	DO14566	HNSC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.7031
p.L114F	DO231186	LUSC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.1111
p.R126I	DO50076	UCEC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.8102
p.C121R	DO50078	UCEC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.3056
p.G123E	SIDM02039	Colorectal Carcinoma	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.6087
p.V118M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.2222
p.V118M	ACH-002256	Leukemia	CCLE	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.2222
p.V118M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.2222
p.G116D	SIDM01588	Endometrial Carcinoma	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.1667
p.F133L	CW-2	large intestine	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.6981
p.S141N	Jurkat	haematopoietic and lymphoid tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.1389
p.S126P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation altering degron motif	0.6752
p.R143H	SNU-1040	large intestine	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	122:134	Mutation rewiring degron network	0.0833

Kaplan plot for TMEM30A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM30A

UniProt ID: Q9NV96

Entrez ID: 55754

Protein name: Cell cycle control protein 50A (P4-ATPase flippase complex beta subunit TMEM30A) (Transmembrane protein 30A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM30A in