DegronMD

Uniprot ID: Q9NV96

Source protein: Cell cycle control protein 50A

Source gene: TMEM30A

Class: DEG_CRL4_CDT2_1

Location: 122:134

E3 ligase: DTL

DEGRON score: 0.6166

ASA_SCORE: 54.8846

COIL: 0.3973

CONS_SCORE: 0.8139

DSS_SCORE: 0.1545

HELIX: 0.0727

FCONS_SCORE: 1.4279

RIG_SCORE: 0.8465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R133H	TCGA-AJ-A3EK	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.8244
p.R133H	TCGA-B5-A3FA	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.8244
p.V135M	TCGA-DD-AACN	LIHC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.3056
p.N144H	TCGA-E6-A1LX	UCEC	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.0556
p.G116C	TCGA-EB-A299	SKCM	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1667
p.G116C	TCGA-ER-A19B	SKCM	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1667
p.K112M	TCGA-MH-A561	KIRP	TCGA	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1667
p.K112M	DO48509	KIRP	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1667
p.P131T	DO14566	HNSC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.7031
p.L114F	DO231186	LUSC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1111
p.R126I	DO50076	UCEC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.8102
p.C121R	DO50078	UCEC	ICGC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.3056
p.G123E	SIDM02039	Colorectal Carcinoma	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.6087
p.V118M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.2222
p.V118M	ACH-002256	Leukemia	CCLE	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.2222
p.V118M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.2222
p.G116D	SIDM01588	Endometrial Carcinoma	GDSC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1667
p.F133L	CW-2	large_intestine	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.6981
p.S141N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.1389
p.S126P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.6752
p.R143H	SNU-1040	large_intestine	COSMIC	YGLSNFYQNHRRY	DEG_CRL4_CDT2_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NV96	Cell cycle control protein 50A	DEG_CRL4_CDT2_1	122:134	YGLSNFYQNHRRY	DTL	0.6166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons