DegronMD - Q9NVH1(DNAJC11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I464V	TCGA-DU-7309	LGG	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5965
p.N466D	TCGA-HU-A4H4	STAD	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5821
p.R450Q	TCGA-SJ-A6ZI	UCEC	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.1111
p.T466M	DO227549	COCA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7423
p.P474H	DO20917	KIRP	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.1111
p.T466K	DO229027	LICA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7306
p.A468D	DO229026	LICA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2778
p.D449G	DO49657	LIHC	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.0833
p.T451I	DO27987	OV	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.1389
p.A471V	DO37866	SKCM	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation substituting flanking lysine	0.3056
p.S461L	DO42793	UCEC	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.7667
p.K471E	SIDM00373	Endometrial Carcinoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation substituting flanking lysine	0.3056
p.K471E	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation substituting flanking lysine	0.3056
p.N466S	SIDM00208	Glioblastoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5958
p.N466S	ACH-002229	Brain Cancer	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5958
p.N466S	D-502MG	central nervous system	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation altering degron motif	0.5958
p.S448C	SIDM01726	Ewing's Sarcoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.0556
p.E454D	SIDM01658	Unknown	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222
p.E454D	ACH-000598	Myeloma	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222
p.L449F	SNU-C5	large intestine	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.0833
p.E470D	MDA-MB-453	breast	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	458:466	Mutation rewiring degron network	0.2222

Kaplan plot for DNAJC11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC11

UniProt ID: Q9NVH1

Entrez ID: 55735

Protein name: DnaJ homolog subfamily C member 11

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJC11 in