DegronMD

Uniprot ID: Q9NVH1

Source protein: DnaJ homolog subfamily C member 11

Source gene: DNAJC11

Class: DEG_APCC_DBOX_1

Location: 458:466

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.616

ASA_SCORE: 42.6444

COIL: 0.3709

CONS_SCORE: 0.635

DSS_SCORE: 0.056

HELIX: 0.0801

FCONS_SCORE: 1.3938

RIG_SCORE: 0.8692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I464V	TCGA-DU-7309	LGG	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	0.5965
p.N466D	TCGA-HU-A4H4	STAD	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	0.5821
p.R450Q	TCGA-SJ-A6ZI	UCEC	TCGA	SRMGLIIVN	DEG_APCC_DBOX_1	0.1111
p.T466M	DO227549	COCA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.7423
p.P474H	DO20917	KIRP	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.1111
p.T466K	DO229027	LICA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.7306
p.A468D	DO229026	LICA	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.2778
p.D449G	DO49657	LIHC	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.0833
p.T451I	DO27987	OV	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.1389
p.A471V	DO37866	SKCM	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.3056
p.S461L	DO42793	UCEC	ICGC	SRMGLIIVN	DEG_APCC_DBOX_1	0.7667
p.K471E	SIDM00373	Endometrial Carcinoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	0.3056
p.K471E	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	0.3056
p.N466S	SIDM00208	Glioblastoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	0.5958
p.N466S	ACH-002229	Brain Cancer	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	0.5958
p.N466S	D-502MG	central_nervous_system	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	0.5958
p.S448C	SIDM01726	Ewing's Sarcoma	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	0.0556
p.E454D	SIDM01658	Unknown	GDSC	SRMGLIIVN	DEG_APCC_DBOX_1	0.2222
p.E454D	ACH-000598	Myeloma	CCLE	SRMGLIIVN	DEG_APCC_DBOX_1	0.2222
p.L449F	SNU-C5	large_intestine	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	0.0833
p.E470D	MDA-MB-453	breast	COSMIC	SRMGLIIVN	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVH1	DnaJ homolog subfamily C member 11	DEG_APCC_DBOX_1	458:466	SRMGLIIVN	APC,CDC20,FZR1	0.616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons