DegronMD - Q9NVN3(RIC8B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D354H	TCGA-66-2773	LUSC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354H	DO26536	LUSC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E372K	TCGA-A5-A0G2	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E372K	DO41235	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.L363V	TCGA-B0-4945	KIRC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6765
p.L363V	DO18144	KIRC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.6765
p.D354Y	TCGA-BS-A0UF	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354Y	DO41488	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354Y	ACH-000870	Lung Cancer	CCLE	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.L369V	TCGA-E6-A1LX	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2778
p.L369V	DO41020	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2778
p.L370V	TCGA-EO-A22U	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.L370V	DO43755	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.D354E	TCGA-F5-6814	READ	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354E	DO36556	READ	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354N	DO218173	BRCA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.E350K	DO234317	ESAD	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0833
p.H377R	DO233146	GACA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.A376S	DO229035	LICA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0833
p.R371H	CESS	haematopoietic and lymphoid tissue	COSMIC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.R358Q	HCC2998	large intestine	COSMIC	YREGLTPVL	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.3056

Kaplan plot for RIC8B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIC8B

UniProt ID: Q9NVN3

Entrez ID: 55188

Protein name: Synembryn-B (Brain synembryn) (hSyn) (Protein Ric-8B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIC8B in