DegronMD

Uniprot ID: Q9NVN3

Source protein: Synembryn-B

Source gene: RIC8B

Class: DEG_APCC_DBOX_1

Location: 359:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5212

ASA_SCORE: 49.9889

COIL: 0.5646

CONS_SCORE: 0.6257

DSS_SCORE: 0.2057

HELIX: 0.2606

FCONS_SCORE: 0.9951

RIG_SCORE: 0.7783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D354H	TCGA-66-2773	LUSC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.D354H	DO26536	LUSC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.E372K	TCGA-A5-A0G2	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.E372K	DO41235	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.L363V	TCGA-B0-4945	KIRC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.6765
p.L363V	DO18144	KIRC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.6765
p.D354Y	TCGA-BS-A0UF	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.D354Y	DO41488	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.D354Y	ACH-000870	Lung Cancer	CCLE	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.L369V	TCGA-E6-A1LX	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.2778
p.L369V	DO41020	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.2778
p.L370V	TCGA-EO-A22U	UCEC	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.25
p.L370V	DO43755	UCEC	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.25
p.D354E	TCGA-F5-6814	READ	TCGA	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.D354E	DO36556	READ	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.D354N	DO218173	BRCA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.1944
p.E350K	DO234317	ESAD	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.0833
p.H377R	DO233146	GACA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.0556
p.A376S	DO229035	LICA	ICGC	YREGLTPVL	DEG_APCC_DBOX_1	0.0833
p.R371H	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	YREGLTPVL	DEG_APCC_DBOX_1	0.2222
p.R358Q	HCC2998	large_intestine	COSMIC	YREGLTPVL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVN3	Synembryn-B	DEG_APCC_DBOX_1	359:367	YREGLTPVL	APC,CDC20,FZR1	0.5212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons