DegronMD - Q9NVN8(GNL3L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S519L	TCGA-2F-A9KR	BLCA	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation blocking phosphorylation signal	0.6944
p.S519L	DO51862	BLCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation blocking phosphorylation signal	0.6944
p.T532M	TCGA-2W-A8YY	CESC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	TCGA-BR-8382	STAD	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	TCGA-GM-A2DC	BRCA	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	DO1866	BRCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	DO223732	CESC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	DO231610	LINC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.T532M	DO47925	STAD	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2778
p.R522H	TCGA-AP-A0LM	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R522H	DO43306	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R522H	SIDM00217	Colorectal Carcinoma	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R522H	ACH-000999	Colon/Colorectal Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.R522H	SNU-1040	large intestine	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7133
p.S513I	TCGA-B5-A3FA	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation blocking phosphorylation signal	0.5278
p.S513I	DO52402	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation blocking phosphorylation signal	0.5278
p.D521N	TCGA-B5-A3FC	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.D521N	DO41871	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.D521N	SIDM00007	Other Solid Cancers	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.D521N	ACH-001550	Skin Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.D521N	MCC13	skin	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.3056
p.M514I	TCGA-FS-A1ZM	SKCM	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1111
p.M514I	DO37731	SKCM	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.1111
p.P534L	TCGA-GN-A268	SKCM	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2222
p.P534L	DO37477	SKCM	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation rewiring degron network	0.2222
p.R522C	DO222864	COCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.719
p.R522C	DO52365	LUSC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.719
p.R522C	DO35118	PACA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.719
p.L526P	SIDM00596	Endometrial Carcinoma	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7582
p.L526P	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7582
p.L526P	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7582
p.L526P	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7582
p.L526P	HEC-1	endometrium	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.7582
p.V525A	ACH-001521	Skin Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	522:530	Mutation altering degron motif	0.5825

Kaplan plot for GNL3L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GNL3L

UniProt ID: Q9NVN8

Entrez ID: 54552

Protein name: Guanine nucleotide-binding protein-like 3-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GNL3L in