DegronMD

Uniprot ID: Q9NVN8

Source protein: Guanine nucleotide-binding protein-like 3-like protein

Source gene: GNL3L

Class: DEG_APCC_DBOX_1

Location: 522:530

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8358

ASA_SCORE: 87.9444

COIL: 0.3029

CONS_SCORE: 0.2339

DSS_SCORE: 0.4086

HELIX: 0.6707

FCONS_SCORE: 0.9775

RIG_SCORE: 0.7996

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S519L	TCGA-2F-A9KR	BLCA	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.6944
p.S519L	DO51862	BLCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.6944
p.T532M	TCGA-2W-A8YY	CESC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	TCGA-BR-8382	STAD	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	TCGA-GM-A2DC	BRCA	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	DO1866	BRCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	DO223732	CESC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	DO231610	LINC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.T532M	DO47925	STAD	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.2778
p.R522H	TCGA-AP-A0LM	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.7133
p.R522H	DO43306	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.7133
p.R522H	SIDM00217	Colorectal Carcinoma	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	0.7133
p.R522H	ACH-000999	Colon/Colorectal Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.7133
p.R522H	SNU-1040	large_intestine	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	0.7133
p.S513I	TCGA-B5-A3FA	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.5278
p.S513I	DO52402	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.5278
p.D521N	TCGA-B5-A3FC	UCEC	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.3056
p.D521N	DO41871	UCEC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.3056
p.D521N	SIDM00007	Other Solid Cancers	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	0.3056
p.D521N	ACH-001550	Skin Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.3056
p.D521N	MCC13	skin	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	0.3056
p.M514I	TCGA-FS-A1ZM	SKCM	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.1111
p.M514I	DO37731	SKCM	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.1111
p.P534L	TCGA-GN-A268	SKCM	TCGA	RRSVLQRIM	DEG_APCC_DBOX_1	0.2222
p.P534L	DO37477	SKCM	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.2222
p.R522C	DO222864	COCA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.719
p.R522C	DO52365	LUSC	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.719
p.R522C	DO35118	PACA	ICGC	RRSVLQRIM	DEG_APCC_DBOX_1	0.719
p.L526P	SIDM00596	Endometrial Carcinoma	GDSC	RRSVLQRIM	DEG_APCC_DBOX_1	0.7582
p.L526P	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.7582
p.L526P	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.7582
p.L526P	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.7582
p.L526P	HEC-1	endometrium	COSMIC	RRSVLQRIM	DEG_APCC_DBOX_1	0.7582
p.V525A	ACH-001521	Skin Cancer	CCLE	RRSVLQRIM	DEG_APCC_DBOX_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRSVLQRIM

Degron related mutations and impact score

Drug responses associated with GNL3L mutations

All proteins holding degron of RRSVLQRIM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVN8	Guanine nucleotide-binding protein-like 3-like protein	DEG_APCC_DBOX_1	522:530	RRSVLQRIM	APC,CDC20,FZR1	0.8358	More...